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KMID : 0359020080360010044
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Korean Journal of Gastrointestinal Endoscopy
2008 Volume.36 No. 1 p.44 ~ p.47
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A Solitary Colonic Neurofibroma in a Patient without Neurofibromatosis
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Kim Kyeong-Ok
Jang Byung-Ik
Moon Hee-Jung
Lee Sang-Hoon
Lee Jun-Young
Lee Gui-Hyung
Lee Si-Hyung
Park Youn-Sun
Choi Jae-Won
Eun Jong-Ryul
Kim Tae-Nyeun
Lee Heon-Ju
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Abstract
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Neurofibromas are usually manifestations of neurofibromatosis type 1 (Nf1). There are usually multiple lesions on presentation. Solitary neurofibromas of the colon are extremely rare. A 34-year-old Asian male came to our hospital for non-specific findings, except for a complaint of loose stools for 2 months. A colonoscopy was performed. A sessile polyp 0.4 cm in diameter was detected at the sigmoid colon. Microscopically, a biopsy from the polyp showed proliferation of spindle cells in the mucosa, myxoid changes and infiltration of inflammatory cells. Immunohistochemical staining was positive for S-100 protein. The above morphological and immunohistochemical characteristics were consistent with a diagnosis of a neurofibroma. Only 13 cases of isolated colonic neurofibromatosis without Nf1 have been documented in the literature. We report this case as an isolated neurofibroma of the colon is even a rarer manifestation, and only three cases have been published in the clinical literature. (Korean J Gastrointest Endosc 2008;36:44-47)
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KEYWORD
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Neurofibromatosis, Neurofibroma, Colon, S-100 protein
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